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Until the 16th century, doctors used the work of the second-century Greek physician Galen to treat patients. Galen believed sickness was caused by an imbalance of the four bodily humors—blood, phlegm, yellow bile, and black bile—and recommended treatments like bloodletting, purging, and applying heated cups to restore balance. Doctors followed these treatments for more than a millennium, not because they worked, but because the intellectual authority of the ancients seemed to dwarf the value of mere contemporary observation. But around 1500, the Swiss physician Paracelsus noticed that Galenic treatments did not actually make patients better, and that some treatments—like mercury for syphilis—worked even though they made no sense within humoral theory. Paracelsus began to advocate listening to evidence rather than deferring to the authority of the long dead: “The patients are your textbook, the sickbed is your study.” In 1527, he even staged a public burning of Galen’s work. His vision took centuries to take hold—nearly 300 years later, George Washington died after an aggressive bloodletting—because people are more inclined to believe neat and simple stories like Galen’s than to confront messy and complex reality.，更多细节参见Line下载
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